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Article

Role for Ets-2(Thr-72) transcription factor in stage-specific thymocyte development and survival.

The Journal of biological chemistry - 17 Feb 2012

Fisher Ian B, Ostrowski Mike, Muthusamy Natarajan

Abstract excerpt

Interference of Ras signaling deregulates thymocyte development in mouse models. However, the role of Ets-2, a transcription factor that is phosphorylated on a critical threonine residue (Thr-72) by the Ras/MAPK pathway in thymocyte development, has not been defined. Transgenic mice overexpressing a phosphomutant Ets-2 (T72A) in the thymus displayed reduced thymus size associated with a 60-80% reduction in...

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Identifiers

PMID: 22128184
DOI: 10.1074/jbc.M111.242602
PMCID: PMC3285301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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