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Article

Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression.

Clinical & experimental metastasis - 1 Apr 2011

Fang Wei Bin, Jokar Iman, Chytil Anna, Moses Harold L, Abel Ty, Cheng Nikki

Abstract excerpt

Accumulation of fibroblasts is a phenomenon that significantly correlates with formation of aggressive cancers. While studies have shown that the TGF-β signaling pathway is an important regulator of fibroblast activation, the functional contribution of TGF-β signaling in fibroblasts during multi-...

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Share to Antigens, Polyomavirus Transforming
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Share to Mammary Neoplasms, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Tumor Virus, Mouse

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Share to Receptor, Transforming Growth Factor-beta Type II

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Source

Open in PubMed Open full text

Identifiers

PMID: 21374085
DOI: 10.1007/s10585-011-9373-0
PMCID: PMC3373018

Genes

CCL2
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21374085-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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