Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin.

Cancer research - 15 Jul 2006

Guo Hong, Miao Hui, Gerber Lizabeth, Singh Jarnail, Denning Mitchell F, Gilliam Anita C, Wang Bingcheng

Abstract excerpt

EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We report here that deletion of EphA2 in mouse led to markedly enhanced susceptibility to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 9,10-Dimethyl-1,2-benzanthracene
Share to Carcinogens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Growth Processes

Share to Keratinocytes

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 16849550
DOI: 10.1158/0008-5472.CAN-06-0004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin.PMID 16849550Read ↗

EphA2 Receptor Tyrosine Kinase as a Promising Target for Cancer TherapeuticsSemantic proximity Read ↗

Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.Semantic proximity Read ↗

Comprehensive analysis of EphA2 in pan-cancer: A prognostic biomarker associated with cancer immunity.Semantic proximity Read ↗

Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progressionSemantic proximity Read ↗

Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancerSemantic proximity Read ↗

Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressiveness.Semantic proximity Read ↗

Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.Semantic proximity Read ↗

Up-regulation of EphA2 and down-regulation of EphrinA1 are associated with the aggressive phenotype and poor prognosis of malignant glioma.Semantic proximity Read ↗

MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice.Semantic proximity Read ↗

Loss of EphA2 receptor tyrosine kinase reduces ApcMin/+ tumorigenesis.Semantic proximity Read ↗

Mouse skin as a model for cancer chemoprevention by nonsteroidal anti-inflammatory drugs.Semantic proximity Read ↗

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.