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Article

MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.

American journal of human genetics - 1 Dec 2003

Brant Steven R, Panhuysen Carolien I M, Nicolae Dan, Reddy Deepthi M, Bonen Denise K, Karaliukas Reda, Zhang Leilei, Swanson Eric, Datta Lisa W, Moran Thomas, Ravenhill Geoffrey, Duerr Richard H, Achkar Jean-Paul, Karban Amir S, Cho Judy H

Abstract excerpt

Crohn disease (CD) and ulcerative colitis (UC) are overlapping chronic inflammatory bowel diseases (IBDs). Suggestive evidence for linkage at chromosome 7q has been reported for both CD and UC. Contained within this region is the gene for MDR1 (multidrug resistance), a membrane transport protein for which human polymorphisms have been reported in Ala893Ser/Thr and C3435T that alter pharmacokinetic profiles for a...

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Identifiers

PMID: 14610718
DOI: 10.1086/379927
PMCID: PMC1180394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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