Article
VH gene usage by family members affected with chronic lymphocytic leukaemia.
British journal of haematology - 1 Dec 1999
Pritsch O, Troussard X, Magnac C, Mauro F R, Davi F, Payelle-Brogard B, Dumas G, Pulik M, Clerget F, Mandelli F, Chiorazzi N, Schroeder H W, Leporrier M, Dighiero G
Abstract excerpt
The excess risk of chronic lymphocytic leukaemia (CLL) in the first-degree relatives of affected patients suggests that familial CLL might constitute a useful model to study the pathogenesis of this disease, as has been demonstrated in numerous other neoplastic disorders. Previous studies have shown non-random utilization of immunoglobulin genes in CLL, some germline in sequence and others containing numerous...
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