Article

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999-09-15

Abstract excerpt

Despite having several characteristics of naı̈ve B cells, chronic lymphocytic leukemia (CLL) cells have been shown in some cases to have somatically mutated Ig variable region genes, indicating that the cell of origin has passed through the germinal center. A previous study of patients with CLL found an association between lack of somatic mutation and trisomy 12 and, therefore, possibly with a less favorable progn...

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Literature Corpus work: 28182615-6b3c-56e0-9ede-7c03858385a2
DOI: 10.1182/blood.v94.6.1848.418k05_1848_1854

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