Article
Insight into the pathogenesis of chronic lymphocytic leukemia (CLL) through analysis of IgVH gene usage and mutation status in familial CLL.
Blood - 15 Jun 2008
Crowther-Swanepoel Dalemari, Wild Ruth, Sellick Gabrielle, Dyer Martin J S, Mauro Francesca R, Cuthbert Robert J G, Jonsson Viggo, Matutes Estella, Dearden Claire, Wiley James, Fuller Stephen, Catovsky Daniel, Houlston Richard S
Abstract excerpt
To address the proposition that familial B-cell chronic lymphocytic leukemia (CLL) may exhibit a more restricted phenotype than sporadic CLL with respect to immunoglobulin gene usage or ontogenic development, we compared immunoglobulin (Ig) heavy chain variable region (VH) gene usage and IgVH mutation status in 327 patients with CLL from 214 families with 724 patients with sporadic cases. The frequency of mutated...
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