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Article

Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins.

Blood - 15 Oct 2004

Widhopf George F, Rassenti Laura Z, Toy Traci L, Gribben John G, Wierda William G, Kipps Thomas J

Abstract excerpt

We examined the immunoglobulin (Ig) heavy chain variable region genes (V(H) genes) used by leukemia cells of 1220 unrelated patients with chronic lymphocytic leukemia (CLL). We found 1188 (97%) expressed Ig encoded by a single Ig V(H) subgroup, the most common of which was V(H)3 (571 or 48.1%), followed by V(H)1 (319 or 26.8%) and V(H)4 (241 or 20.2%). Using allele-specific primers, we found 13.8% of all samples...

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PMID: 15217828
DOI: 10.1182/blood-2004-03-0818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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