Article
Subcellular localization of cyclic nucleotide phosphodiesterase type 10A variants, and alteration of the localization by cAMP-dependent protein kinase-dependent phosphorylation.
The Journal of biological chemistry - 6 Feb 2004
Kotera Jun, Sasaki Takashi, Kobayashi Tamaki, Fujishige Kotomi, Yamashita Yoko, Omori Kenji
Abstract excerpt
Our previous studies have suggested that two phosphodiesterase type 10A (PDE10A) variants, PDE10A1 and PDE10A2 transcripts, are mainly expressed in humans and that PDE10A2 and PDE10A3 transcripts are major variants in rats. In the present study, immunoblot analysis demonstrated that PDE10A proteins, especially PDE10A2, are more abundant in membrane fractions than in cytosolic fractions of rat striatum....
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