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Article

Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71.

Nucleic acids research - 15 Nov 2003

Oberdoerffer Philipp, Otipoby Kevin L, Maruyama Mitsuo, Rajewsky Klaus

Abstract excerpt

The Cre/loxP recombination system is a commonly used tool to alter the mouse genome in a conditional manner by deletion or inversion of loxP-flanked DNA segments. While Cre-mediated deletion is essentially unidirectional, inversion is reversible and therefore does not allow the stable alteration of gene function in cells that constitutively express Cre. Site-directed mutagenesis yielded a pair of asymmetric loxP...

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Identifiers

PMID: 14602933
DOI: 10.1093/nar/gng140
PMCID: PMC275577

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