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Article

Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus.

Applied and environmental microbiology - 1 Nov 2003

Tamehiro Norimasa, Hosaka Takeshi, Xu Jun, Hu Haifeng, Otake Noboru, Ochi Kozo

Abstract excerpt

Working with a Streptomyces albus strain that had previously been bred to produce industrial amounts (10 mg/ml) of salinomycin, we demonstrated the efficacy of introducing drug resistance-producing mutations for further strain improvement. Mutants with enhanced salinomycin production were detected at a high incidence (7 to 12%) among spontaneous isolates resistant to streptomycin (Str(r)), gentamicin, or rifampin...

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Identifiers

PMID: 14602594
DOI: 10.1128/AEM.69.11.6412-6417.2003
PMCID: PMC262278

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