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Article

Mutations within gene XNR_2147 for TetR-like protein enhance lincomycin resistance and endogenous specialized metabolism of Streptomyces albus J1074.

Journal of applied genetics - 1 Feb 2023

Tseduliak Vasylyna-Marta, Dolia Borys, Ostash Iryna, Lopatniuk Maria, Busche Tobias, Ochi Kozo, Kalinowski Jörn, Luzhetskyy Andriy, Fedorenko Victor, Ostash Bohdan

Abstract excerpt

Streptomyces albus J1074 is one of the most popular heterologous expression platforms among streptomycetes. Identification of new genes and mutations that influence specialized metabolism in this species is therefore of great applied interest. Here, we describe S. albus KO-1304 that was isolated as a spontaneous lincomycin-resistant variant of double rpsLR94G rsmGR15SG40E mutant KO-1295. Besides altered...

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PMID: 36417169
DOI: 10.1007/s13353-022-00738-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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