Affected paroxysmal nocturnal hemoglobinuria T lymphocytes harbor a common defect in assembly of N-acetyl-D-glucosamine inositol phospholipid corresponding to that in class A Thy-1- murine lymphoma mutants.

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Article

Affected paroxysmal nocturnal hemoglobinuria T lymphocytes harbor a common defect in assembly of N-acetyl-D-glucosamine inositol phospholipid corresponding to that in class A Thy-1- murine lymphoma mutants.

The Journal of biological chemistry - 15 Dec 1992

Armstrong C, Schubert J, Ueda E, Knez J J, Gelperin D, Hirose S, Silber R, Hollan S, Schmidt R E, Medof M E

Abstract excerpt

Deficient expression of glycoinositol phospholipid (GPI) anchored proteins in affected paroxysmal nocturnal hemoglobinuria (PNH) cells has been traced to a defect in GPI anchor assembly. In a previous study (Schubert, J., Schmidt, R. E., and Medof, M. E. (1993) J. Biol. Chem., in press) we characterized the biosynthesis of putative Man-containing GPI anchor precursors in normal peripheral blood lymphocytes and...

Topics

Acetylglucosamine
Animals
Antigens, CD
CD48 Antigen
Cell Membrane
Dolichol Monophosphate Mannose
Glycosylphosphatidylinositols
Hemoglobinuria, Paroxysmal
Humans
Killer Cells, Natural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma

Mannose

Mice

Mutation

Neutrophils

Trypanosoma brucei brucei

Uridine Diphosphate N-Acetylglucosamine

Source

Open in PubMed

Identifiers

PMID: 1460030

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1460030-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Affected paroxysmal nocturnal hemoglobinuria T lymphocytes harbor a common defect in assembly of N-acetyl-D-glucosamine inositol phospholipid corresponding to that in class A Thy-1- murine lymphoma mutants.PMID 1460030Read ↗

Deficient biosynthesis of N-acetylglucosaminyl-phosphatidylinositol, the first intermediate of glycosyl phosphatidylinositol anchor biosynthesis, in cell lines established from patients with paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

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