Article
[Mutations in the PIG-A gene lead to GPI-deficiency in paroxysmal nocturnal hemoglobinuria].
Immunitat und Infektion - 1 Aug 1994
Ostendorf T, Schubert J, Schmidt R E
Abstract excerpt
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by the deficiency of glycosylphosphatidylinositol-(GPI-)-anchored surface molecules on blood cells. The biochemical basis of this deficiency is the lack of the first GPI biosynthesis intermediate GlcNAc-PI in the deficient cells correspon...
Topics
- Glycosylphosphatidylinositols
- Hemoglobinuria, Paroxysmal
- Humans
- Membrane Proteins
- Mutation
- RNA, Messenger