Article
Differential expression of glycosylphosphatidylinositol-anchored proteins in a murine T cell hybridoma mutant producing limiting amounts of the glycolipid core. Implications for paroxysmal nocturnal hemoglobinuria.
The Journal of clinical investigation - 1 Apr 1992
Thomas L J, Urakaze M, DeGasperi R, Kamitani T, Sugiyama E, Chang H M, Warren C D, Yeh E T
Abstract excerpt
A T cell hybridoma mutant, which expressed a markedly reduced level of glycosylphosphatidylinositol (GPI)-anchored proteins on the cell surface, was characterized. The surface expression level of Thy-1 was approximately 17% of the wild-type level, whereas the surface expression of Ly-6A was appro...
Topics
- Animals
- Glycolipids
- Glycosylphosphatidylinositols
- Hemoglobinuria, Paroxysmal
- Hybridomas
- Membrane Proteins
- Mice
- Mutation
- Phosphatidylinositols
- T-Lymphocytes