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Article

The pathophysiology of disease in patients with paroxysmal nocturnal hemoglobinuria.

Hematology. American Society of Hematology. Education Program - 1 Jan 2008

Bessler Monica, Hiken Jeffrey

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia caused by the expansion of a hematopoietic progenitor cell that has acquired a mutation in the X-linked PIGA gene. PNH occurs on the background of bone marrow failure. Bone marrow failure and the presence of the abnormal cells account for the clinical phenotype of patients with PNH including hemolysis, cytopenia, and thrombophilia. PIGA is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Glycosylphosphatidylinositols

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Source

Identifiers

PMID: 19074066
DOI: 10.1182/asheducation-2008.1.104

Genes

PIGA
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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