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Article

A new aspect of the molecular pathogenesis of paroxysmal nocturnal hemoglobinuria.

Hematology (Amsterdam, Netherlands) - 1 Aug 2002

Shichishima Tsutomu, Noji Hideyoshi

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematologic disorder which is manifest by complement-mediated hemolysis, venous thrombosis, and bone marrow failure. Complement-mediated hemolysis in PNH is explained by the deficiency of glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59 on erythrocyte surfaces. All the PNH patients had phosphatidylinositol glycan-class A (PIG-A)...

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PMID: 14972783
DOI: 10.1080/1024533021000024094

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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