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Article

T cells from paroxysmal nocturnal haemoglobinuria (PNH) patients show an altered CD40-dependent pathway.

Journal of leukocyte biology - 1 Jul 2005

Terrazzano Giuseppe, Sica Michela, Becchimanzi Cristina, Costantini Silvia, Rotoli Bruno, Zappacosta Serafino, Alfinito Fiorella, Ruggiero Giuseppina

Abstract excerpt

Paroxysmal nocturnal haemoglobinuria (PNH) is a haematopoiesis disorder characterized by the expansion of a stem cell bearing a somatic mutation in the phosphatidylinositol glycan-A (PIG-A) gene, which is involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) anchor. A number of data suggest the inability of the PIG-A mutation to account alone for the clonal dominance of the GPI-defective clone...

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Identifiers

PMID: 15817705
DOI: 10.1189/jlb.0105026

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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T cells from paroxysmal nocturnal haemoglobinuria (PNH) patients show an altered CD40-dependent pathway.PMID 15817705Read ↗

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