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Article

Paroxysmal nocturnal hemoglobinuria without GPI-anchor deficiency.

The Journal of clinical investigation - 2 Dec 2019

Brodsky Robert A

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder characterized by hemolysis, thrombosis, and bone marrow failure caused by defective expression of glycosylphosphatidylinositol-anchored (GPI-anchored) complement inhibitors. Most commonly, PNH is caused by loss of function of PIGA, which is required for GPI biosynthesis. In this issue of the JCI, Höchsmann et al. report on 4 PNH patients who also...

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Identifiers

PMID: 31638602
DOI: 10.1172/JCI131647
PMCID: PMC6877310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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