PIG-A gene abnormalities in Thai patients with paroxysmal nocturnal hemoglobinuria.

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Article

PIG-A gene abnormalities in Thai patients with paroxysmal nocturnal hemoglobinuria.

The Southeast Asian journal of tropical medicine and public health - 1 Jan 1995

Pramoonjago P, Wanachiwanawin W, Chinprasertsuk S, Pattanapanyasat K, Takeda J, Kinoshita T

Abstract excerpt

Deficient biosynthesis of the glycosyl phosphatidyl inositol (GPI)-anchor in blood cells is implicated in the pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH). Abnormal clonal cells appear in various hematopoietic cell lineages, suggesting that PNH arises as a result of somatic mutation...

Topics

DNA Transposable Elements
DNA, Complementary
Glycosylphosphatidylinositols
Granulocytes
Hemoglobinuria, Paroxysmal
Humans
Membrane Proteins
Mutation
Neutrophils
Phenotype
Polymerase Chain Reaction
RNA, Messenger
Sequence Deletion
Thailand

Source

Open in PubMed

Identifiers

PMID: 8629134

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8629134-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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