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Article

Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003

Akagi Tsuyoshi, Sasai Ken, Hanafusa Hidesaburo

Abstract excerpt

Human cells are known to be more refractory than rodent cells against oncogenic transformation in vitro. To date, the molecular mechanisms underlying such resistance remain largely unknown. The combination of simian virus 40 early region and H-Ras V12 has been effective for transformation of rat embryo fibroblasts, but not for human cells. However, the additional ectopic expression of the telomerase catalytic...

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Share to Antigens, Polyomavirus Transforming
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14597713
DOI: 10.1073/pnas.1834876100
PMCID: PMC263854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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