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Article

Dissection of the Drosophila paired protein: functional requirements for conserved motifs.

Mechanisms of development - 1 Aug 1994

Cai J, Lan Y, Appel L F, Weir M

Abstract excerpt

The Drosophila paired gene encodes three conserved motifs: a homeodomain, paired domain and PRD (his/pro) repeat. To investigate the functional importance of the PRD repeat and paired domain, we tested deletion mutants using an ectopic expression assay in embryos. Our results suggest that the PRD repeat is not required for the in vivo regulation of the target genes, engrailed and gooseberry. However, the PRD...

Topics

Amino Acid Sequence
Animals
Cell Line
Chromosome Deletion
DNA-Binding Proteins
Drosophila
Homeodomain Proteins
Molecular Sequence Data
Multigene Family
Mutation
Proline
Protein Structure, Tertiary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

Transcription, Genetic

Source

Identifiers

PMID: 7811637
DOI: 10.1016/0925-4773(94)90086-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7811637-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Dissection of the Drosophila paired protein: functional requirements for conserved motifs.PMID 7811637Read ↗

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