Article
The functional conservation of proteins in evolutionary alleles and the dominant role of enhancers in evolution.
The EMBO journal - 15 Jul 1996
Xue L, Noll M
Abstract excerpt
Drosophila paired- embryos can be rescued to viable adults by the evolutionary alleles prd-Gsb and prd-Pax3, which express the Drosophila Gooseberry and mouse Pax3 proteins under the control of the paired cis-regulatory region. As prd-Gsb uncovers a prd function involved in the proper abdominal s...
Topics
- Alleles
- Animals
- Animals, Genetically Modified
- Base Sequence
- Binding Sites
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Enhancer Elements, Genetic
- Evolution, Molecular
- Gene Dosage
- Homeodomain Proteins
- Mice
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- PAX3 Transcription Factor
- Paired Box Transcription Factors
- Phenotype