Article
The functional conservation of proteins in evolutionary alleles and the dominant role of enhancers in evolution.
The EMBO journal - 15 Jul 1996
Xue L, Noll M
Abstract excerpt
Drosophila paired- embryos can be rescued to viable adults by the evolutionary alleles prd-Gsb and prd-Pax3, which express the Drosophila Gooseberry and mouse Pax3 proteins under the control of the paired cis-regulatory region. As prd-Gsb uncovers a prd function involved in the proper abdominal segmentation of adults, evolutionary alleles, defined and constructed in this manner, may often be weak and thus serve...
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