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Regulation of the Human Cholesterol 7α-Hydroxylase Gene (CYP7A1) by Thyroid Hormone in Transgenic Mice

4 Nov 2003

Abstract excerpt

Thyroid hormones exert significant changes in the metabolism of bile acids. However, in humans, the effect of thyroid hormone on cholesterol 7alpha-hydroxylase (cyp7a), the rate- controlling enzyme in the classical bile acid biosynthetic pathway, remains poorly understood and has been difficult to study directly in vivo. Previous studies from our laboratory have shown that the activity of the human cholesterol...

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PMID: 14592954
DOI: 10.1210/en.2003-0993

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