Article
Increased plasma thyroid hormone concentrations in LDL receptor deficient mice may be explained by inhibition of aryl hydrocarbon receptor-dependent expression of hepatic UDP-glucuronosyltransferases.
Biochimica et biophysica acta - 1 Apr 2012
Gessner Denise K, Ringseis Robert, Möller Carolin, Eder Klaus
Abstract excerpt
BACKGROUND: Overexpression of SREBP-1 causes a repression of hepatic genes involved in phase II metabolism. In LDL receptor deficient (LDLR(-/-)) mice, active levels of SREBP-1 in the liver are increased. We investigated the hypothesis that LDLR(-/-) mice have increased concentrations of thyroid hormones in plasma due to a reduced hepatic glucuronidation. METHODS: Female LDLR(-/-) and wild-type mice were used to...
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