Article
Promoter variant -204A > C of the cholesterol 7α-hydroxylase gene: association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells.
Clinical nutrition (Edinburgh, Scotland) - 1 Apr 2011
De Castro-Orós Isabel, Pampín Sandra, Cofán Montserrat, Mozas Pilar, Pintó Xavier, Salas-Salvadó Jordi, Rodríguez-Rey Jose C, Ros Emilio, Civeira Fernando, Pocoví Miguel
Abstract excerpt
BACKGROUND & AIMS: The bile acid pool influences intestinal cholesterol absorption because this process is strictly dependent on micellar solubilization, which is disrupted by plant sterols (PS). Plasma lipid variation relates to promoter variant -204A > C (rs3808607) of the CYP7A1 gene encoding for 7α-hydroxylase, an enzyme for bile acid synthesis. We hypothesized that this polymorphism would be associated with...
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