Article
Expression of human cholesterol 7alpha-hydroxylase in atherosclerosis-susceptible mice via adenovirus infection.
The Biochemical journal - 15 Jun 1997
Moore G L, Drevon C A, Machleder D, Trawick J D, McClelland A, Roy S, Lyons R, Jambou R, Davis R A
Abstract excerpt
Adenovirus is a vector for the delivery of genes mainly to the liver. Short-term (approximately 3 days) studies using adenovirus transfection have provided valuable insights into how genes can complement normal and pathological phenotypes. When atherosclerosis-susceptible C57BL/6 mice were infected with an adenovirus vector containing the human 7alpha-hydroxylate cDNA (AV17h1) and fed on a chow diet, human...
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