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Article

Liver X Receptor-α Gene Expression Is Positively Regulated by Thyroid Hormone

13 Jul 2007

Abstract excerpt

The nuclear oxysterol receptors, liver X receptors (LXRs), and thyroid hormone receptors (TRs) cross talk mutually in many aspects of transcription, sharing the same DNA binding site (direct repeat-4) with identical geometry and polarity. In the current study, we demonstrated that thyroid hormone (T(3)) up-regulated mouse LXR-alpha, but not LXR-beta, mRNA expression in the liver and that cholesterol...

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PMID: 17628006
DOI: 10.1210/en.2007-0150

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