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Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings.

Basic & clinical pharmacology & toxicology - 1 Mar 2012

Xiang Xiaoqiang, Backman Janne T, Neuvonen Pertti J, Niemi Mikko

Abstract excerpt

Cholesterol 7α-hydroxylase (CYP7A1) is the rate-limiting enzyme of bile acid production in human beings, and organic anion-transporting polypeptide 1B1 (OATP1B1) may influence bile acid hepatic uptake and cholesterol and bile acid synthesis rate. Our purpose was to investigate the effects of gender and CYP7A1 and SLCO1B1 polymorphisms on the fasting plasma concentrations of bile acids, bile acid synthesis marker...

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PMID: 21902813
DOI: 10.1111/j.1742-7843.2011.00792.x

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