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Article

Human Sterol 27-Hydroxylase (CYP27) Overexpressor Transgenic Mouse Model

1 Sept 2002

Abstract excerpt

CYP27-overexpressed transgenic mice were generated with the use of a human full-length CYP27 coding region cloned into a ubiquitous expression vector. Positive transgenic mice were identified by tail DNA genotyping and high fecal 27-hydroxycholesterol content. The levels of 27-hydroxycholesterol were found to be 3-5 times higher in the circulation and the tissues of the overexpressed mice when compared with...

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PMID: 12119285
DOI: 10.1074/jbc.m201122200

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