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Article

Disruption of the oxysterol 7alpha-hydroxylase gene in mice.

The Journal of biological chemistry - 2 Jun 2000

Li-Hawkins J, Lund E G, Turley S D, Russell D W

Abstract excerpt

Mice without oxysterol 7alpha-hydroxylase, an enzyme of the alternate bile acid synthesis pathway with a sexually dimorphic expression pattern, were constructed by the introduction of a null mutation at the Cyp7b1 locus. Animals heterozygous (Cyp7b1(+/-)) and homozygous (Cyp7b1(-/-)) for this mutation were grossly indistinguishable from wild-type mice. Plasma and tissue levels of 25- and 27-hydroxycholesterol,...

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PMID: 10748048
DOI: 10.1074/jbc.M001811200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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