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Article

Multiple cellular consequences of isocitrate dehydrogenase isozyme dysfunction.

Archives of biochemistry and biophysics - 15 Nov 2003

McCammon Mark T, McAlister-Henn Lee

Abstract excerpt

To probe the functions of multiple forms of isocitrate dehydrogenase in Saccharomyces cerevisiae, mutants lacking three of the isozymes were constructed and analyzed. Results show that, while the mitochondrial NAD+-dependent enzyme, IDH (composed of Idh1p and Idh2p subunits) is not the major contributor to total isocitrate dehydrogenase activity under any growth condition, loss of IDH produces the most dramatic...

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Source

Identifiers

PMID: 14592466
DOI: 10.1016/j.abb.2003.08.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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