An unassembled subunit of NAD(+)-dependent isocitrate dehydrogenase is insoluble and covalently modified.

doi:10.1006/abbi.1998.0677

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Article

An unassembled subunit of NAD(+)-dependent isocitrate dehydrogenase is insoluble and covalently modified.

Archives of biochemistry and biophysics - 1 Jun 1998

Gadde D M, Yang E, McCammon M T

Abstract excerpt

The NAD(+)-dependent isocitrate dehydrogenase of Saccharomyces cerevisiae is an octamer composed of four Idh1p subunits and four Idh2p subunits. Isocitrate dehydrogenase functions in the tricarboxylic acid cycle and has also been reported to bind to the 5' nontranslated region of mitochondrially encoded mRNAs. Mutants defective in either or both of these subunits are unable to grow on the nonfermentable carbon...

Topics

Fungal Proteins
Isocitrate Dehydrogenase
Macromolecular Substances
Mitochondria
Molecular Weight
Mutation
Oxidation-Reduction
Protein Binding
Protein Processing, Post-Translational
Saccharomyces cerevisiae
Solubility

Source

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Identifiers

PMID: 9633603
DOI: 10.1006/abbi.1998.0677

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