Metabolic alterations in yeast lacking copper-zinc superoxide dismutase.

doi:10.1016/j.freeradbiomed.2011.03.004

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Article

Metabolic alterations in yeast lacking copper-zinc superoxide dismutase.

Free radical biology & medicine - 1 Jun 2011

Sehati Sadaf, Clement Matthew H S, Martins Jake, Xu Lei, Longo Valter D, Valentine Joan S, Gralla Edith B

Abstract excerpt

Yeast lacking copper-zinc superoxide dismutase (sod1∆) have a number of oxygen-dependent defects, including auxotrophies for lysine and methionine and sensitivity to oxygen. Here we report additional defects in metabolic regulation. Under standard growth conditions with glucose as the carbon source, yeast undergo glucose repression in which mitochondrial respiration is deemphasized, energy is mainly derived from...

Topics

Cell Growth Processes
Cell Respiration
Cytochromes c
Ethanol
Glucose
Lysine
Methionine
Mitochondria
Mutation
Oxidative Stress
Oxygen
Oxygen Consumption
Saccharomyces cerevisiae Proteins
Superoxide Dismutase
Yeasts

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Open in PubMed Open full text

Identifiers

PMID: 21397007
DOI: 10.1016/j.freeradbiomed.2011.03.004
PMCID: PMC3090513

Genes

CYC1

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