Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Physiological consequences of loss of allosteric activation of yeast NAD+-specific isocitrate dehydrogenase.

The Journal of biological chemistry - 23 Jun 2006

Hu Gang, Lin An-Ping, McAlister-Henn Lee

Abstract excerpt

Based on allosteric regulatory properties, NAD+-specific isocitrate dehydrogenase (IDH) is believed to control flux through the tricarboxylic acid cycle in vivo. To distinguish growth phenotypes associated with regulatory dysfunction of this enzyme in Saccharomyces cerevisiae, we analyzed strains expressing well defined mutant forms of IDH or a non-allosteric bacterial NAD+-specific isocitrate dehydrogenase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Site
Share to Carbon
Share to Ethanol

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Gene Expression Regulation, Fungal

Share to Genes, Fungal

Share to Isocitrate Dehydrogenase

Share to Oxygen Consumption

Source

Identifiers

PMID: 16621803
DOI: 10.1074/jbc.M512281200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physiological consequences of loss of allosteric activation of yeast NAD+-specific isocitrate dehydrogenase.PMID 16621803Read ↗

Kinetic and physiological effects of alterations in homologous isocitrate-binding sites of yeast NAD(+)-specific isocitrate dehydrogenase.Semantic proximity Read ↗

Multiple cellular consequences of isocitrate dehydrogenase isozyme dysfunction.Semantic proximity Read ↗

Kinetic analysis of NAD(+)-isocitrate dehydrogenase with altered isocitrate binding sites: contribution of IDH1 and IDH2 subunits to regulation and catalysis.Semantic proximity Read ↗

Expression and gene disruption analysis of the isocitrate dehydrogenase family in yeast.Semantic proximity Read ↗

Kinetic properties and metabolic contributions of yeast mitochondrial and cytosolic NADP+-specific isocitrate dehydrogenases.Semantic proximity Read ↗

Hap4 is not essential for activation of respiration at low specific growth rates in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sources of NADPH and expression of mammalian NADP+-specific isocitrate dehydrogenases in Saccharomyces cerevisiae.Semantic proximity Read ↗

Isocitrate binding at two functionally distinct sites in yeast NAD+-specific isocitrate dehydrogenase.Semantic proximity Read ↗

Subunit structure, expression, and function of NAD(H)-specific isocitrate dehydrogenase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes.Semantic proximity Read ↗

Understanding the impact of the cofactor swapping of isocitrate dehydrogenase over the growth phenotype of Escherichia coli on acetate by using constraint-based modeling.Semantic proximity Read ↗

Physiological and genetic analysis of the carbon regulation of the NAD-dependent glutamate dehydrogenase of Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.