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Article

Effects of excess succinate and retrograde control of metabolite accumulation in yeast tricarboxylic cycle mutants.

The Journal of biological chemistry - 30 Sept 2011

Lin An-Ping, Anderson Sondra L, Minard Karyl I, McAlister-Henn Lee

Abstract excerpt

Cellular and mitochondrial metabolite levels were measured in yeast TCA cycle mutants (sdh2Δ or fum1Δ) lacking succinate dehydrogenase or fumarase activities. Cellular levels of succinate relative to parental strain levels were found to be elevated ~8-fold in the sdh2Δ mutant and ~4-fold in the fum1Δ mutant, and there was a preferential increase in mitochondrial levels in these mutant strains. The sdh2Δ and fum1Δ...

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Identifiers

PMID: 21841001
DOI: 10.1074/jbc.M111.266890
PMCID: PMC3190802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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