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Article

Suppression of metabolic defects of yeast isocitrate dehydrogenase and aconitase mutants by loss of citrate synthase.

Archives of biochemistry and biophysics - 1 Jun 2008

Lin An-Ping, Hakala Kevin W, Weintraub Susan T, McAlister-Henn Lee

Abstract excerpt

Yeast mutants lacking mitochondrial NAD(+)-specific isocitrate dehydrogenase (idhDelta) or aconitase (aco1Delta) were found to share several growth phenotypes as well as patterns of specific protein expression that differed from the parental strain. These shared properties of idhDelta and aco1Delta strains were eliminated or moderated by co-disruption of the CIT1 gene encoding mitochondrial citrate synthase. Gas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18359281
DOI: 10.1016/j.abb.2008.03.005
PMCID: PMC2459229

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