Article
Loss of ARF/INK4A Promotes Liver Progenitor Cell Transformation Toward Tumorigenicity Supporting Their Role in Hepatocarcinogenesis.
Gene expression - 12 Jun 2020
Strauss Robyn P, Audsley Katherine M, Passman Adam M, van Vuuren Joanne H, Finch-Edmondson Megan L, Callus Bernard A, Yeoh George C
Abstract excerpt
Liver progenitor cells (LPCs) contribute to liver regeneration during chronic damage and are implicated as cells of origin for liver cancers including hepatocellular carcinoma (HCC). The CDKN2A locus, which encodes the tumor suppressors alternate reading frame protein (ARF) and INK4A, was identified as one of the most frequently altered genes in HCC. This study demonstrates that inactivation of CDKN2A enhances...
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