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Article

Molecular mechanisms regulating protein kinase Czeta turnover and cellular transformation.

The Biochemical journal - 15 Feb 2004

Le Good J Ann, Brindley David N

Abstract excerpt

The regulation of protein kinase C (PKC)zeta in relation to its turnover, cell growth and transformation was investigated in Rat2 fibroblasts by over-expressing wild-type or mutant forms of PKCzeta. Deletion of the pseudosubstrate site (PSS) produced the most active mutant (PKCzeta Delta PSS), but mutants designed to mimic phosphorylated PKCzeta had lower specific activities in an in vitro assay. The mutant...

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Identifiers

PMID: 14580237
DOI: 10.1042/BJ20031194
PMCID: PMC1223926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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