Article
Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?
The oncologist - 1 Jan 2002
da Rocha A B, Mans D R A, Regner A, Schwartsmann G
Abstract excerpt
A large body of evidence suggests that the abnormal phenotype of neoplastic astrocytes, including their excessive proliferation rate and high propensity to invade surrounding tissues, results from mutations in critical genes involved in key cellular events. These genetic alterations can affect cell-surface-associated receptors, elements of signaling pathways, or components of the cell cycle clock, conferring a...
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