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Article

Protein kinase Czeta is a negative regulator of protein kinase B activity.

The Journal of biological chemistry - 26 Mar 1999

Doornbos R P, Theelen M, van der Hoeven P C, van Blitterswijk W J, Verkleij A J, van Bergen en Henegouwen P M

Abstract excerpt

Protein kinase B (PKB), also known as Akt or RAC-PK, is a serine/threonine kinase that can be activated by growth factors via phosphatidylinositol 3-kinase. In this article we show that PKCzeta but not PKCalpha and PKCdelta can co-immunoprecipitate PKB from CHO cell lysates. Association of PKB with PKCzeta was also found in COS-1 cells transiently expressing PKB and PKCzeta, and moreover we found that this...

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Identifiers

PMID: 10085094
DOI: 10.1074/jbc.274.13.8589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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