PKC-zeta-associated CK2 participates in the turnover of free IkappaBalpha.

Abstract excerpt

The atypical PKC isoenzymes, zeta and iota, activate NF-kappaB, a mechanism thought to mediate the anti-apoptotic and proliferative features of these kinases. PKC-zeta has been shown to be associated with an IkappaBalpha kinase in resting cells. In this study, we have sought to identify the PKC-zeta associated kinase and understand how PKC-zeta mediates basal IkappaBalpha turnover in vivo. We demonstrate that the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Casein Kinase II
• Share to Half-Life
• Share to Heparin