Article
Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout".
Synapse (New York, N.Y.) - 1 Jan 2004
Tomiyama Katsunori, McNamara Fergal N, Clifford Jeremiah J, Kinsella Anthony, Drago John, Fuchs Sara, Grandy David K, Low Malcolm J, Rubinstein Marcelo, Tighe Orna, Croke David T, Koshikawa Noriaki, Waddington John L
Abstract excerpt
Using a novel system, the role of D2-like dopamine receptors in distinct topographies of orofacial movement was assessed in mutant mice with congenic D2 vs. D3 receptor knockout, and compared with findings in D1A mutants. Under spontaneous conditions, D2 mutants evidenced increased vertical jaw movements and unaltered horizontal jaw movements, with reductions in tongue protrusions and incisor chattering; in D3...
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