Article
Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors.
Neuroscience - 1 Jan 1999
Jung M Y, Skryabin B V, Arai M, Abbondanzo S, Fu D, Brosius J, Robakis N K, Polites H G, Pintar J E, Schmauss C
Abstract excerpt
Within the D2-class of dopamine receptors, the D2 and D3 subtypes share the highest degree of similarity in their primary structure. However, the extent to which these two receptor subtypes have similar or different functional properties is unclear. The present study used gene targeting to generate mice deficient for D2, D3, and D2/D3 receptors. A comparative analysis of D2 and D3 single mutants and D2/D3 double...
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