Article
Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice.
Progress in neuro-psychopharmacology & biological psychiatry - 17 Mar 2009
Tomiyama Katsunori, O'Tuathaigh Colm M, O'Sullivan Gerard J, Kinsella Anthony, Lai Donna, Harvey Richard P, Tighe Orna, Croke David T, Koshikawa Noriaki, Waddington John L
Abstract excerpt
Studies in antipsychotic-naïve patients with schizophrenia indicate a baseline level of spontaneous involuntary movements, particularly orofacial dyskinesia. Neuregulin-1 is associated with risk for schizophrenia and its functional role can be studied in 'knockout' mice. We have shown previously that neuregulin-1 'knockouts' evidence disruption in social behaviour. Neuregulin-1 'knockouts' were assessed for four...
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