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Article

Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2004

Kobayashi Minoru, Iaccarino Ciro, Saiardi Adolfo, Heidt Valérie, Bozzi Yuri, Picetti Roberto, Vitale Carmine, Westphal Heiner, Drago John, Borrelli Emiliana

Abstract excerpt

Dopamine (DA) controls a wide variety of physiological functions in the central nervous system as well as in the neuroendocrine and gastrointestinal systems. DA signaling is mediated by five cloned receptors named D1-D5. Knockout mouse models for the five receptors have been generated, and, albeit impaired for some important DA-mediated functions, they are viable and can reproduce. D1 and D2 receptors are the...

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Identifiers

PMID: 15272078
DOI: 10.1073/pnas.0402028101
PMCID: PMC509223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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