Article
Phenotypic disruption to orofacial movement topography in conditional mutants with generalized CamKIIa/Cre D1Tox versus striatal-specific DARPP-32/Cre D1Tox ablation of D1 dopamine receptor-expressing cells.
Synapse (New York, N.Y.) - 1 Sept 2011
Tomiyama Katsunori, Kim Hyun Ah, Kinsella Anthony, Ehrlich Michelle E, Schütz Günter, Koshikawa Noriaki, Lawrence Andrew J, Waddington John L, Drago John
Abstract excerpt
Orofacial movements were quantified in (a) DARPP-32/Cre D1Tox mutants, having progressive loss of D1 dopamine receptor expressing striatal medium spiny neurons and (b) CamKIIa/Cre D1Tox mutants, having progressive, generalized loss of forebrain D1 receptor expressing cells. Horizontal jaw movements and tongue protrusions were reduced in DARPP-32/Cre but not in CamKIIa/Cre mutants; head and vibrissae movements...
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