Article
Phenotypic, ethologically based resolution of spontaneous and D(2)-like vs D(1)-like agonist-induced behavioural topography in mice with congenic D(3) dopamine receptor "knockout".
Synapse (New York, N.Y.) - 1 Oct 2002
McNamara Fergal N, Clifford Jeremiah J, Tighe Orna, Kinsella Anthony, Drago John, Fuchs Sara, Croke David T, Waddington John L
Abstract excerpt
Uncertainty as to the functional role of the D(3) dopamine receptor, due primarily to a paucity of selective agonists or antagonists, is being addressed in mice with targeted gene deletion ("knockout") thereof. This study describes, for the first time, the phenotype of congenic D(3)-null mice. Initially, 129/Sv x C57BL/6 D(3)-null mice were backcrossed 14 times onto C57BL/6; they were then assessed using an...
Topics
- 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
- Animals
- Behavior, Animal
- Dopamine Agonists
- Exploratory Behavior
- Female
- Habituation, Psychophysiologic
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenethylamines