Article
Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10 years at the psychopharmacology-molecular biology interface.
Psychopharmacology - 1 Oct 2005
Waddington John L, O'Tuathaigh Colm, O'Sullivan Gerard, Tomiyama Katsunori, Koshikawa Noriaki, Croke David T
Abstract excerpt
BACKGROUND: Mutants with targeted gene deletion ('knockout') or insertion (transgenic) of D1, D2, D3, D4 and D5 dopamine (DA) receptor subtypes are complemented by an increasing variety of double knockout and transgenic-'knockout' models, together with knockout of critical components of DA receptor signalling cascades such as G alpha(olf)[G gamma7], adenylyl cyclase type 5, PKA [RIIbeta] and DARPP-32. However, it...
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