Article
Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11.
Genomics - 15 Apr 2001
Watters J W, Dietrich W F
Abstract excerpt
Lethal factor (LF) is a toxin secreted by Bacillus anthracis that plays an important role in the pathogenesis of anthrax. Intoxication with LF results in a macrophage-specific cytolysis that is not well understood. Interestingly, inbred mouse strains exhibit dramatic differences in the susceptibility of their cultured macrophages to killing by LF, and a gene that influences this phenotype, called Ltxs1, has been...
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